The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in children
نویسندگان
چکیده
منابع مشابه
The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in children
BACKGROUND Pretreatment auxological variables, such as birth size and parental heights, are important predictors of the growth response to GH treatment. For children with missing pretreatment data, published prediction models cannot be used. The objective was to construct and validate a prediction model for children with missing background data based on the observed first-year growth response t...
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AIM To study the relationship between insulin sensitivity and growth response in short children born small for gestational age (SGA) treated with growth hormone (GH). METHODS Randomized, open-label, 24-month intervention study in 40 short prepubertal SGA children [age (mean ± SD) 5.3 ± 1.5 years], who either remained untreated (n = 20) or were treated with GH (66 µg/kg/day; n = 20). Changes i...
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BACKGROUND Noonan syndrome (NS) is an autosomal dominant disorder characterized by specific features including short stature, distinctive facial dysmorphic features, congenital heart defects, hypertrophic cardiomyopathy, skeletal anomalies and webbing of the neck. Molecular screening has shown that the majority of individuals with NS have a mutation in the PTPN11 gene. Noonan syndrome children ...
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This study provides a controlled assessment of the psychological (and physical) effects of growth hormone treatment. Fifteen short 'normal' children (height SD score < -2) have been treated with growth hormone since the age of 7/8 years. They, together with untreated short controls and average controls (10th-90th centiles), were assessed at recruitment, after three years, and after five years. ...
متن کاملA new and accurate prediction model for growth response to growth hormone treatment in children with growth hormone deficiency.
OBJECTIVE To identify parameters which predict individual growth response to recombinant human GH (rhGH) therapy and to combine these parameters in a prediction model. DESIGN Fifty-eight prepubertal patients with GH deficiency (17 females) participated in this prospective multicenter trial with 1 year of follow-up. METHODS Auxological measurements, parameters of GH status and markers of bon...
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ژورنال
عنوان ژورنال: BMC Medical Informatics and Decision Making
سال: 2009
ISSN: 1472-6947
DOI: 10.1186/1472-6947-9-1